ProMetic is a biopharmaceutical corporation with globally recognized expertise in bioseparation and uses its own affinity technology for the development of best in class plasma-derived therapeutics. ProMetic is also active in developing its own novel small molecule therapeutics products.
Headquartered in Laval, Canada, ProMetic has a global presence through its various sites in the UK and USA, providing both manufacturing and R&D capability. These strategic locations facilitate ProMetic’s growth globally and supports all business activity in American, European and Asian markets.
ProMetic is publicly traded on TSX (Symbol: PLI) and OTCQX (Symbol: PFSCF).
ProMetic has developed core competencies in strategic fields, including:
- Purification of biologics
- Drug development
- Elimination of pathogens
The business is now focused on developing its range of therapeutics from both its plasma-derived and small-molecule platform.
Through developing industry-leading affinity technology, ProMetic is now using its own affinity technology for the extraction and purification of therapeutics proteins from human plasma.
Through its proprietary Plasma Protein Purification System (PPPS™), ProMetic is targeting the extraction of multiple high value proteins from a single plasma sample at unprecedented activity levels.
PPPS™ is a sequential, multi-product purification process that employs powerful affinity separation materials to extract and purify commercially important plasma proteins in high yields.
ProMetic is now operating since late 2013 its own plasma purification facility in Canada where it is recovering therapeutic proteins from plasma for its own clinical trial needs and initial commercial requirements.
ProMetic’s strategy is driven through its subsidiaries who work cohesively to pool their skills and develop state-of-the-art processes, equipmentand products. ProMetic’s operating subsidiaries work together to deliver these therapeutic products:
- ProMeticBioProductionInc. (PBP), based in Laval, Quebec, Canada
- ProMeticBioTherapeuticsInc. (PBT), based in Rockville, MD, USA
- ProMeticBioSciencesLtd. (PBL), based in the United Kingdom (Isle of Man and Cambridge)
ProMetic’s small-molecule drug discovery is focused on developing orally active drugs that cater for unmet medical applications, such as:
- Autoimmune diseases
These first-in-class therapeutics typically have efficacy and high safety profiles confirmed in several in vivo experiments, and enjoy strong proprietary positions.
ProMetic’s Therapeutics is focused on advancing and partnering promising drug candidates following the completion of in vivo proof-of-concept studies, with a number of candidates in the pipeline.
An example of ProMetic’s small-molecule drug discovery program is PBI-4050, an orally active lead drug candidate with excellent safety and efficacy profiles confirmed various clinical trials in patients suffering from chronic kidney diseases and metabolic syndrome.
PBI-4050 has a number of ongoing clinical trials targeting rare diseases and unmet medical conditions such as idiopathic pulmonary fibrosis, chronic kidney disease, metabolic syndrome and associated type 2 diabetes. The findings of ProMetic’s groundbreaking studies have been presented and published at a number of international conferences.
ProMetic’s small molecule Therapeutics operation is spearheaded by its subsidiary centered at ProMeticBioSciencesInc., based in Laval, Quebec, Canada.