Protein Technologies
Bioseparation Products for Drug Purification
ProMetic’s core bioseparation technologies, its proprietary affinity adsorbents and its Mimetic Ligand™ purification platform are used by numerous pharmaceutical and biopharmaceutical companies, and have made ProMetic a key supplier to the global life sciences industry. The chemical diversity of ProMetic’s ligand libraries allows for the selection of almost any target protein.
ProMetic’s technology allows for the capture of multiple targeted proteins directly from the source product, and then for the separation of these nearly identical proteins to achieve greater yields with high levels of purity. As a result, manufacturing clients using ProMetic’s bioseparation technologies experience significant reductions in costs associated to drug purification.
How it works (WMV -393 kb)
Furthermore, pharmaceutical and biomanufacturing communities – seven of whose leading antibody producers participated in a performance testing of ProMetic’s technology – are relentlessly pursuing improved process yields and efficiencies. ProMetic’s new MAbsorbent™ ligands targeting the purification of monoclonal antibodies (“MAbs”) and recombinant antibody fragments (“Fabs”), strongly position ProMetic to generate revenues from the consistent growth in demand for antibody therapeutics. The market for MAbs currently exceeds $16 billion.
Moreover, ProMetic’s purification bioprocess was once again validated using 800 liters of commercial Mimetic Ligand™. This affinity adsorbent was packed in a 1.8 meter diameter process chromatography column for GMP manufacture of a biological product. End results confirmed that the product performance met all of our client’s specifications.
Currently, thirteen of ProMetic’s proprietary affinity products are used as part of the manufacturing process or as a component of ten biopharmaceutical or biomedical products approved for sale in the U.S. and/or in Europe. Several additional products being developed by pharmaceutical and biopharmaceutical companies also rely upon ProMetic’s technology.
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